#5157 ESTIMATION OF RENAL KT/V FROM 24-HOUR URINE VOLUME AND UREA DISTRIBUTION VOLUME IN PERITONEAL DIALYSIS

Abstract Background and Aims Residual renal function is an important factor in peritoneal dialysis (PD) regarding technical survival implementation of incremental therapy schemes. The aim the retrospective study was to develop estimation formula Kt/Vurea PD based on urine output anthropometric data. Method In 235 adult patients (151 males, 84 females, median age 66 years, BMI 26.0, diuresis >100 ml/day) registered together with lab data during first equilibration test. dose furosemide noted. Urea distribution volume calculated using DuBois. Measurement urea blood performed by a standard kinetic test urease. Results 24-hour ranged from 100 3800 ml (median 1150 ml), similar both sexes. Renal Kturea showed significant linear correlation daily (r=0.78, p<0.01) independent sex diuretic dose: = 5.116 + 0.0221 x (renal liters/week, ml). varied between 24 60 liters 36.4 liters), Kt/V 0.05 2.57 0.84). Estimated Kt/V, before mentioned equation divided volume, correlated significantly (r=0.75, p<0.01). goodness fit analysis mean absolute error 0.24. Bland-Altman Plot confirmed tendency over-estimation for < 1.0 under-estimation higher Kt/V. A restriction up 1500 (n=142 patients, 69 25) resulted improvement (goodness analysis: 0.20). Conclusion seems be feasible utilizing